CB1R antagonist 2
CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS -induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models[1].
Product Specifications
UNSPSC
12352005
Target
Cannabinoid Receptor; NF-κB; p38 MAPK
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NN(C2=CC=CC=C2)C(C3CCCCC3)=N1)N(C)/C=C\C4=CC=CC=C4
Molecular Formula
C24H26N4O
Molecular Weight
386.49
References & Citations
[1]Wang L, et al., Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist. Eur J Med Chem. 2025 Feb 27;289:117461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC681081-500 1x 500 µL
CD45RO (190-2F2.5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472748-500 1x 500 µL
AMACR / p504S (Prostate Cancer Marker) (AMACR/2748R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470857-100 1x 100 µL
WT1 (Wilm's Tumor 1) (WT1/857), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401237-500 1x 500 µL
P27 / KIP1 (DCS-72.F6 + KIP1/769 (SX53G8) ), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details