CB1R antagonist 2
CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056) -induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models[1].
Product Specifications
UNSPSC
12352005
Target
Cannabinoid Receptor; NF-κB; p38 MAPK
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NN(C2=CC=CC=C2)C(C3CCCCC3)=N1)N(C)/C=C\C4=CC=CC=C4
Molecular Formula
C24H26N4O
Molecular Weight
386.49
References & Citations
[1]Wang L, et al., Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist. Eur J Med Chem. 2025 Feb 27;289:117461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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