KOR agonist 5
KOR agonist 5 (Compound 10a) is a KOR/MOR modulator with agonistic activity towards KOR and antagonistic activity towards MOR. KOR agonist 5 can effectively block morphine-induced antinociception and inhibition of intestinal motility. KOR agonist 5 can be used in the research of Substance Use Disorder (SUD) [1].
Product Specifications
UNSPSC
12352005
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Smiles
COC1=C(O2)C([C@@]3([C@@H]2[C@]4(OC)[C@@H](C(C5=CC(NC(C6=CC=CC=C6)=O)=CC=C5)=O)C7)[C@@]7(C=C4)C(N(CC8CC8)CC3)C9)=C9C=C1
Molecular Formula
C38H38N2O5
Molecular Weight
602.72
References & Citations
[1]Tang S, et al. Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities. Eur J Med Chem. 2025 Feb 26;289:117449.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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