MAPK-IN-4
MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent. MAPK-IN-4 can inhibit the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS (HY-D1056) . MAPK-IN-4 can bind to IRAK4 and exert its anti-inflammatory effect by inhibiting the MAPK pathway[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; IRAK; p38 MAPK
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Smiles
N[C@@H]1CC[C@H](OC2=C3C=C(OC)C(OCC4=CC=CC(Br)=C4)=CC3=NC=N2)CC1
Molecular Formula
C22H24BrN3O3
Molecular Weight
458.35
References & Citations
[1]Guo M, et al. Anti-inflammatory agents design via the fragment hybrid strategy in the discovery of compound c1 for treating ALI and UC. Eur J Med Chem. 2025 Feb 25;289:117431.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172406/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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