CDC20-IN-2

CDC20-IN-2 (14c), a Cdc20 inhibitor (KD: 7.65 μM), causes G2/M phase arrest and promotes DNA damage accumulation. CDC20-IN-2 (14c) stabilizes key substrates such as Cyclin B1 and Bim, leading to enhanced apoptosis and suppression of tumor cell proliferation and migration[1].

Product Specifications

CAS Number

[3080812-16-1]

UNSPSC

12352005

Target

APC; Apoptosis

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC(F)(F)C1=CC=C(NC2=CC(Cl)=NC(NC(NC(OCCNC(C3=CN=C(C(F)(F)F)S3)=O)=O)C(Cl)(Cl)Cl)=N2)C=C1

Molecular Formula

C21H15Cl4F6N7O3S

Molecular Weight

701.26

References & Citations

[1]Xiangyang Le, et al. Design, synthesis and optimization of Apcin analogues as Cdc20 inhibitors for triple-negative breast cancer therapy. Eur J Med Chem. 2025 May 5:289:117434.