FXIa-IN-16
FXIa-IN-16 (Compound 43) is an orally active and selective Factor XIa (FXIa) inhibitor with an IC50 of 0.19 nM. FXIa-IN-16 exhibits strong anticoagulant and antithrombotic activities and shows good safety in mice. FXIa-IN-16 can be used in the research related to the treatment of thrombosis[1].
Product Specifications
CAS Number
[3046390-69-3]
UNSPSC
12352005
Target
Factor XI
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C1N(CC2=NC=CC(C3=C(F)N=C(N)C=C3)=C2)C=C(OC)C(C4=CC(Cl)=CC=C4N5C=NN=N5)=C1
Molecular Formula
C24H18ClFN8O2
Molecular Weight
504.90
References & Citations
[1]Zhang Y, et al. Discovery of potent, highly selective, and orally bioavailable factor XIa inhibitors for anticoagulant therapy. Eur J Med Chem. 2025 Feb 25;289:117436.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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