PD-L1/VISTA-IN-2
PD-L1/VISTA-IN-2 (Compound S8) is an orally active bifunctional PD-L1/VISTA inhibitor with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. PD-L1/VISTA-IN-2 can activate the tumor immune microenvironment and exert anti-cancer effects[1].
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1; VISTA
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OCCNCC(C=C1)=C(OC)N=C1C2=C3C(C4=CC=CC=C4OC3)=CC=C2
Molecular Formula
C22H22N2O3
Molecular Weight
362.42
References & Citations
[1]Xiao Y, et al. Discovery of bifunctional small molecules targeting PD-L1/VISTA with favorable pharmacokinetics for cancer immunotherapy. Bioorg Chem. 2025 Mar 1;157:108323.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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