PD-L1/VISTA-IN-2

PD-L1/VISTA-IN-2 (Compound S8) is an orally active bifunctional PD-L1/VISTA inhibitor with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. PD-L1/VISTA-IN-2 can activate the tumor immune microenvironment and exert anti-cancer effects[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1; VISTA

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OCCNCC(C=C1)=C(OC)N=C1C2=C3C(C4=CC=CC=C4OC3)=CC=C2

Molecular Formula

C22H22N2O3

Molecular Weight

362.42

References & Citations

[1]Xiao Y, et al. Discovery of bifunctional small molecules targeting PD-L1/VISTA with favorable pharmacokinetics for cancer immunotherapy. Bioorg Chem. 2025 Mar 1;157:108323.