TopoII/tubulin-IN-1

TopoII/tubulin-IN-1 (Compound 1B8) is a TopoII/tubulin inhibitor. TopoII/tubulin-IN-1 can inhibit the proliferation and the level of ROS of tumor cells, induce apoptosis and cell cycle arrest of tumor cells, but has no significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS) ; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

COC1=C(OC)C(OC)=CC(C2=CC(C3=CC=CC=C3Cl)=NC(N4C=NN=C4)=N2)=C1

Molecular Formula

C21H18ClN5O3

Molecular Weight

423.85

References & Citations

[1]Yadav UP, et al. Design and development of new substituted pyrimidine hybrids with imidazole and triazole: Exploring utility as an anticancer agent via human topoisomerase-II and tubulin inhibition. Bioorg Chem. 2025 Mar 1;158:108334.