Thalidomide-NH-C4-Boc

Thalidomide-NH-C4-Boc is the conjugate composed of an E3 ligase (Cereblon) ligand and a linker that can be used for synthesis of PROTAC CARM1/IKZF3 degrader-1 (HY-172368) [1].

Product Specifications

CAS Number

[2226139-38-2]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C1N(C2C(NC(CC2)=O)=O)C(C3=C(NCCCCCC(OC(C)(C)C)=O)C=CC=C31)=O

Molecular Formula

C23H29N3O6

Molecular Weight

443.49

References & Citations

[1]Ni W, et al. Dual CARM1-and IKZF3-targeting: a novel approach to multiple myeloma therapy Synergy between CARM1 inhibition and IMiDs[J]. Molecular Therapy Oncology, 2025.