PROTAC CARM1/IKZF3 degrader-1
PROTAC CARM1/IKZF3 degrader-1 (Compound 074) inhibits CARM1, reduces the methylation level of its substrate BAF155. PROTAC CARM1/IKZF3 degrader-1 is the PROTAC degrader for IKZF 1/3 through a CRBN-dependent pathway. PROTAC CARM1/IKZF3 degrader-1 inhibits the expression of MYC protein, thereby inhibiting the proliferation of a variety of multiple myeloma cells. PROTAC CARM1/IKZF3 degrader-1 induces apoptosis in cell H929. PROTAC CARM1/IKZF3 degrader-1 overcomes immunomodulatory drugs (IMiD, such as pomalidomide) resistance. PROTAC CARM1/IKZF3 degrader-1 can be used in cancer and immunology research[1]. (Pink: ligand for target protein CARM1/IKZF3 ligand 1 ; Active form of target protein ligand: EZM 2302 (HY-111109) ; Black: linker (HY-21999) ; Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride (HY-41547) )
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase; IKZF Family; PROTACs
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Smiles
ClC1=C(C2=NC(C3=C(C)ON=C3C)=C(C)C(N4CC5(CCN(C(CCCCCNC6=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=CC=C6)=O)CC5)C4)=N2)C=C(OC[C@@H](CNC)O)C=C1
Molecular Formula
C46H54ClN9O8
Molecular Weight
896.43
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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