PLK1-IN-12

PLK1-IN-12 is a highly selective and orally active PLK1 inhibitor with an IC50 of 20 nM. PLK1-IN-12 shows more selective for PLK1 than PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM) . PLK1-IN-12 exhibits anticancer potency across a broad spectrum of cell lines. PLK1-IN-12 can be used in anti-leukemia research[1].

Product Specifications

UNSPSC

12352005

Target

Polo-like Kinase (PLK)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CN(C1=O)C(C=NC(NC2=C(C(Cl)=CC(N3CCN(CC3)C)=C2)OCCCO)=N4)=C4N([C@@H]1CC)C5CCCC5

Molecular Formula

C28H40ClN7O3

Molecular Weight

558.12

References & Citations

[1]Nie J, et al. Structure-Based Discovery of a Highly Selective, Oral Polo-Like Kinase 1 Inhibitor with Potent Antileukemic Activity. J Med Chem. 2025 Feb 27;68 (4) :4477-4497.