Succinate dehydrogenase-IN-6

Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC50 of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC50s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC50 > 12.5 μg/mL) [1].

Product Specifications

UNSPSC

12352005

Target

Fungal; Succinate Dehydrogenase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C(C(N1)=NC2=C(C=CC=C2)C1=O)NNC3=CC=C(F)C(F)=C3

Molecular Formula

C15H10F2N4O2

Molecular Weight

316.26

References & Citations

[1]Yan T, et al., Discovery of Novel Quinazolinone-2-carbohydrazide Derivatives as Effective Succinate Dehydrogenase Inhibitors and Biosafety Assessment on Rice and Zebrafish. J Agric Food Chem. 2025 Mar 5;73 (9) :5054-5066.