Succinate dehydrogenase-IN-6
Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC50 of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC50s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC50 > 12.5 μg/mL) [1].
Product Specifications
UNSPSC
12352005
Target
Fungal; Succinate Dehydrogenase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C(C(N1)=NC2=C(C=CC=C2)C1=O)NNC3=CC=C(F)C(F)=C3
Molecular Formula
C15H10F2N4O2
Molecular Weight
316.26
References & Citations
[1]Yan T, et al., Discovery of Novel Quinazolinone-2-carbohydrazide Derivatives as Effective Succinate Dehydrogenase Inhibitors and Biosafety Assessment on Rice and Zebrafish. J Agric Food Chem. 2025 Mar 5;73 (9) :5054-5066.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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