PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader 4 (Compound 17c) is the PROTAC degrader for HDAC6 with a DC50 of 14 nM. PROTAC HDAC6 degrader 4 exhibits inhibitory activit against HDAC1, HDAC2, HDAC3 and HDAC6 with IC50s of 2.2, 2.37, 0.61 and 0.295 μM, respectively[1]. (Pink: ligand for target protein HDAC6 ligand-3 (HY-172360) ; Black: linker (HY-138387) ; Blue: ligand for cereblon E3 ligase (HY-W093272) )
Product Specifications
UNSPSC
12352005
Target
HDAC; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(C(NNCC)=O)C=C1)C2=CC=C(OCC3=CN(CCCCCCNC4=CC5=C(C(N(C(CC6)C(NC6=O)=O)C5=O)=O)C=C4F)N=N3)C=C2
Molecular Formula
C39H42FN9O7
Molecular Weight
767.81
References & Citations
[1]Stopper D, et al. Development of Ethyl-Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6
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