H1L1A1B3
H1L1A1B3 is an ionizable cationic lipid used in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA). H1L1A1B3-LNPs demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315. H1L1A1B3 can activate the NF-κB/IRF immune pathways[1].
Product Specifications
CAS Number
3097638-09-7
UNSPSC
12352211
Target
Liposome; NF-κB
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(NC1CCCCC1)C(N(C(CCC(CCCCC)C)=O)CCCN(C)C)CCCCCOC(CCCCCCCCCCC)=O
Molecular Formula
C40H77N3O4
Molecular Weight
664.06
References & Citations
[1]Xu S, et al. Tumor-Tailored Ionizable Lipid Nanoparticles Facilitate IL-12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy. Adv Mater. 2024 Jul;36 (29) :e2400307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb1307083-01 1 mg
Dihydroxyacetone phosphate hemimagnesium hydrate
Sign In for Pricing
View Details orb1307083-02 2 mg
Dihydroxyacetone phosphate hemimagnesium hydrate
Sign In for Pricing
View Details