H1L1A1B3

H1L1A1B3 is an ionizable cationic lipid used in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA) . H1L1A1B3-LNPs demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315 (HY-138170) . H1L1A1B3 can activate the NF-κB/IRF immune pathways[1].

Product Specifications

CAS Number

[3097638-09-7]

UNSPSC

12352211

Target

Liposome; NF-κB

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(NC1CCCCC1)C(N(C(CCC(CCCCC)C)=O)CCCN(C)C)CCCCCOC(CCCCCCCCCCC)=O

Molecular Formula

C40H77N3O4

Molecular Weight

664.06

References & Citations

[1]Xu S, et al. Tumor-Tailored Ionizable Lipid Nanoparticles Facilitate IL-12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy. Adv Mater. 2024 Jul;36 (29) :e2400307.