(R, S, S, S) -Orlistat
(R, S, S, S) -Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL). (R, S, S, S) -Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE[1].
Product Specifications
CAS Number
104872-28-8
Product Name Alternative
(R, S, S, S) -Tetrahydrolipstatin; (R, S, S, S) -Ro-18-0647
UNSPSC
12352211
Target
Fatty Acid Synthase (FASN)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
CC(C)C[C@@H](NC=O)C(O[C@@H](CCCCCCCCCCC)C[C@H]1[C@@H](C(O1)=O)CCCCCC)=O
Molecular Formula
C29H53NO5
Molecular Weight
495.73
References & Citations
[1]Goins CM, et al. Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases. Biochemistry. 2018 Apr 24;57 (16) :2383-2393.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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