(R, S, S, S) -Orlistat

(R, S, S, S) -Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL) (HY-B0218) . (R, S, S, S) -Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE[1].

Product Specifications

CAS Number

[104872-28-8]

Product Name Alternative

(R, S, S, S) -Tetrahydrolipstatin; (R, S, S, S) -Ro-18-0647

UNSPSC

12352211

Target

Fatty Acid Synthase (FASN)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

CC(C)C[C@@H](NC=O)C(O[C@@H](CCCCCCCCCCC)C[C@H]1[C@@H](C(O1)=O)CCCCCC)=O

Molecular Formula

C29H53NO5

Molecular Weight

495.73

References & Citations

[1]Goins CM, et al. Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases. Biochemistry. 2018 Apr 24;57 (16) :2383-2393.