Pyrazole N-Desmethyl sildenafil

Pyrazole N-Desmethyl sildenafil (Compound 10) is an analog of Sildenafil (HY-15025) . Pyrazole N-Desmethyl sildenafil shows 16% inhibition on Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) with 100 µM[1].

Product Specifications

CAS Number

[139755-95-6]

UNSPSC

12352005

Target

Parasite; Phosphodiesterase (PDE)

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Cardiovascular Disease

Smiles

O=C1N=C(C2=C(OCC)C=CC(S(=O)(N3CCN(CC3)C)=O)=C2)NC4=C1NN=C4CCC

Molecular Formula

C21H28N6O4S

Molecular Weight

460.55

References & Citations

[1]Cuihua Wang, et al. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs. Bioorg Med Chem Lett. 2012 Apr 1;22 (7) :2579-81.