Pyrazole N-Desmethyl sildenafil
Pyrazole N-Desmethyl sildenafil (Compound 10) is an analog of Sildenafil. Pyrazole N-Desmethyl sildenafil shows 16% inhibition on Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) with 100 µM[1].
Product Specifications
CAS Number
139755-95-6
UNSPSC
12352005
Target
Parasite; Phosphodiesterase (PDE)
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Cardiovascular Disease
Smiles
O=C1N=C(C2=C(OCC)C=CC(S(=O)(N3CCN(CC3)C)=O)=C2)NC4=C1NN=C4CCC
Molecular Formula
C21H28N6O4S
Molecular Weight
460.55
References & Citations
[1]Cuihua Wang, et al. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs. Bioorg Med Chem Lett. 2012 Apr 1;22 (7) :2579-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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