FKBP12 PROTAC FM4

FKBP12 PROTAC FM4 is a PROTAC degrader of MTH1, with a DC50 values of 0.09–0.22 nM. FKBP12 PROTAC FM4 is composed of PROTAC target protein ligand AP1867-3- (aminoethoxy) (HY-129363) (red part), E3 ligase ligand MTH1 ligand 1 (HY-134724) (blue part) and PROTAC Linker t-Boc-N-amido-PEG5-acetic acid (HY-W190962) (black part), among which the conjugate of PROTAC target protein ligand + Linker is FKBP12 Ligand-Linker Conjugate 2 (HY-172266) [1].

Product Specifications

UNSPSC

12352005

Target

PROTACs

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.95

Smiles

CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC(OCCNC(COCCOCCOCCOCCOCCNC(C4=CC=C(C=N4)C5=CC=C6N=CC(C(NC)=O)=C(C6=C5)NC7=CC=CC=C7)=O)=O)=C3)CCC8=CC(OC)=C(C=C8)OC)=O)=O

Molecular Formula

C73H89N7O17

Molecular Weight

1336.52

References & Citations

[1]Kyle Mangano, et al. VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation. Cell Chem Biol. 2025 Mar 20;32 (3) :423-433.e9.