WEHI-3773
WEHI-3773 is an inhibitor of the interaction between VDAC2 and BAK or BAX. WEHI-3773 inhibits BAX-mediated Apoptosis by blocking the VDAC2-mediated recruitment of BAX to mitochondria. Conversely, WEHI-3773 promotes BAK-mediated Apoptosis by limiting the inhibitory sequestration of BAK by VDAC2. WEHI-3773 is promising for research in the field of anti-cancer [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.89
Smiles
CSC1=CC=C(N2C(/C(C3=C(N)C(C#N)=C(N)N=C32)=C4C(N(C5=CC=C(SC)C=C5)C6=NC(N)=C(C#N)C(N)=C6/4)=O)=O)C=C1
Molecular Formula
C30H22N10O2S2
Molecular Weight
618.69
References & Citations
[1]Li K, et al. Differential regulation of BAX and BAK apoptotic activity revealed by small molecules. Sci Adv. 2025 Mar 7;11 (10) :eadr8146.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Magebl1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
Bovine Endothelial Cell Adhesion Molecule ELISA Kit