WEHI-3773
WEHI-3773 is an inhibitor of the interaction between VDAC2 and BAK or BAX. WEHI-3773 inhibits BAX-mediated Apoptosis by blocking the VDAC2-mediated recruitment of BAX to mitochondria. Conversely, WEHI-3773 promotes BAK-mediated Apoptosis by limiting the inhibitory sequestration of BAK by VDAC2. WEHI-3773 is promising for research in the field of anti-cancer [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.89
Smiles
CSC1=CC=C(N2C(/C(C3=C(N)C(C#N)=C(N)N=C32)=C4C(N(C5=CC=C(SC)C=C5)C6=NC(N)=C(C#N)C(N)=C6/4)=O)=O)C=C1
Molecular Formula
C30H22N10O2S2
Molecular Weight
618.69
References & Citations
[1]Li K, et al. Differential regulation of BAX and BAK apoptotic activity revealed by small molecules. Sci Adv. 2025 Mar 7;11 (10) :eadr8146.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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