YY-23
YY-23 is a selective inhibitor of NMDAR (containing GluN2C or GluN2D) . YY-23 inhibits GABAergic neurotransmission and enhances excitatory transmission by inhibiting NMDARs containing GluN2D on GABAergic interneurons in the prefrontal cortex. YY-23 has antidepressant activity and can be used for the research of neurological diseases[1].
Product Specifications
CAS Number
1365029-75-9
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
98.12
Smiles
CC1=C(O[C@H]2C[C@@]3([H])[C@]4([H])CC[C@@]5(C[C@H](CC[C@@]5([C@@]4([H])CC[C@@]3([C@]21[H])C)C)O)[H])CC[C@@H](CO[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C
Molecular Formula
C33H54O8
Molecular Weight
578.78
References & Citations
[1]Zhang J, et al. An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons. Sci Adv. 2025 Mar 7;11 (10) :eadq0444.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS2078325-01 0.1 mL
Cy3-Linked Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3)
Sign In for Pricing
View Details MBS2078325-02 0.2 mL
Cy3-Linked Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3)
Sign In for Pricing
View Details MBS2078325-03 0.5 mL
Cy3-Linked Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3)
Sign In for Pricing
View Details MBS2078325-04 1 mL
Cy3-Linked Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3)
Sign In for Pricing
View Details MBS2078325-05 5 mL
Cy3-Linked Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3)
Sign In for Pricing
View Details