YY-23
YY-23 is a selective inhibitor of NMDAR (containing GluN2C or GluN2D) . YY-23 inhibits GABAergic neurotransmission and enhances excitatory transmission by inhibiting NMDARs containing GluN2D on GABAergic interneurons in the prefrontal cortex. YY-23 has antidepressant activity and can be used for the research of neurological diseases[1].
Product Specifications
CAS Number
[1365029-75-9]
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
98.12
Smiles
CC1=C(O[C@H]2C[C@@]3([H])[C@]4([H])CC[C@@]5(C[C@H](CC[C@@]5([C@@]4([H])CC[C@@]3([C@]21[H])C)C)O)[H])CC[C@@H](CO[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C
Molecular Formula
C33H54O8
Molecular Weight
578.78
References & Citations
[1]Zhang J, et al. An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons. Sci Adv. 2025 Mar 7;11 (10) :eadq0444.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Curated Selection
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