5-HT2B antagonist-2
5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(O)[C@@H](N)CCC(N1C[C@@H](NS(=O)(C2=CC=C(OC)C(C(NC3=CC=CC=C3Cl)=O)=C2)=O)CC1)=O.Cl
Molecular Formula
C23H28Cl2N4O7S
Molecular Weight
575.46
References & Citations
[1]Yoon J, et al. Synthesis and Biological Evaluation of Peripheral 5HT2B Antagonists for Liver Fibrosis. J Med Chem. 2025 Mar 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
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