HIF-PHD-IN-4

HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. HIF-PHD-IN-4 can effectively enhance the mobilization of hematopoietic stem cells induced by G-CSF in mice at a dose of 2 mg/kg. HIF-PHD-IN-4 is suitable for research in the field of tumor therapy [1].

Product Specifications

CAS Number

[3108252-48-5]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NCC1=CC=NN=C1)C2=C(C(C=CN3C4CCCCC4)=C(C3=O)C=N2)O

Molecular Formula

C20H21N5O3

Molecular Weight

379.41

References & Citations

[1]Wu M, et al. Discovery of Novel, Potent, Orally Bioavailable and Efficacious, Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors for Hematopoietic Stem Cell Mobilization. J Med Chem. 2025 Mar 6.