PI4KIII beta inhibitor 4
PI4KIII beta inhibitor 4 (Compound 16) is a selective PI4KIIIβ inhibitor with an IC50 of 0.005 μM. PI4KIIIβ inhibitor 4 induces tumor cell apoptosis, cell cycle arrest, and autophagy by inhibiting the PI3K/AKT pathway. PI4KIIIβ inhibitor 4 can be used in the study of cancer[1].
Product Specifications
CAS Number
3029505-94-7
UNSPSC
12352005
Target
Akt; Apoptosis; Autophagy; PI3K; PI4K
Related Pathways
Apoptosis; Autophagy; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=S(C1=C(C=CC(C2=C(N=C(S2)NC(CCCCC)=O)C)=C1)OC)(NCCNC(OC(C)(C)C)=O)=O
Molecular Formula
C24H36N4O6S2
Molecular Weight
540.70
References & Citations
[1]Wang B, et al. Discovery of 5-Phenylthiazol-2-amine Derivatives as Novel PI4KIIIβ Inhibitors with Efficacious Antitumor Activity by Inhibiting the PI3K/AKT Axis. J Med Chem. 2025 Mar 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4KIIIβ
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