PI4KIII beta inhibitor 4

PI4KIII beta inhibitor 4 (Compound 16) is a selective PI4KIIIβ inhibitor with an IC50 of 0.005 μM. PI4KIIIβ inhibitor 4 induces tumor cell apoptosis, cell cycle arrest, and autophagy by inhibiting the PI3K/AKT pathway. PI4KIIIβ inhibitor 4 can be used in the study of cancer[1].

Product Specifications

CAS Number

[3029505-94-7]

UNSPSC

12352005

Target

Akt; Apoptosis; Autophagy; PI3K; PI4K

Related Pathways

Apoptosis; Autophagy; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=S(C1=C(C=CC(C2=C(N=C(S2)NC(CCCCC)=O)C)=C1)OC)(NCCNC(OC(C)(C)C)=O)=O

Molecular Formula

C24H36N4O6S2

Molecular Weight

540.70

References & Citations

[1]Wang B, et al. Discovery of 5-Phenylthiazol-2-amine Derivatives as Novel PI4KIIIβ Inhibitors with Efficacious Antitumor Activity by Inhibiting the PI3K/AKT Axis. J Med Chem. 2025 Mar 6.