CSN5-IN-2
CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. CSN5-IN-2 can increase the level of Cullin 1 neddylation, and downregulate the expression of RAD51 and PD-L1 in cancer cells. CSN5-IN-2 has anti-tumor activity, and its effect is better when combined with Talazoparib.
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1; RAD51
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Field of Research
Cancer
Smiles
CC1=CC=C(C2=CC3=C(C=CN=C3N2)NCCN4CCN(CC4)C(CN5CCOCC5)=O)C(C6=CC=CC=C6)=C1
Molecular Formula
C32H38N6O2
Molecular Weight
538.68
References & Citations
[1]Lei P, et al. Discovery of New Azaindole Metallo-Deubiquitinase CSN5 Inhibitors. J Med Chem. 2025 Mar 27;68 (6) :6748-6765.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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