FGFR-IN-17
FGFR-IN-17 (Compound 12l) is an orally active irreversible inhibitor of FGFR, which has a strong inhibitory effect on FGFR and its mutants. FGFR-IN-17 can inhibit the proliferation and migration, and induce apoptosis of non-small cell lung cancer cells. FGFR-IN-17 has anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FGFR
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=CC(NC1=CC=C(NC2=NC(NC3=CC=C(N4C[C@@H](C)N[C@@H](C)C4)C(OC)=C3)=NC=C2Cl)C=C1Cl)=O
Molecular Formula
C26H29Cl2N7O2
Molecular Weight
542.46
References & Citations
[1]Zhang J, et al. Discovery of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent and Selective FGFR Inhibitors against Gatekeeper Mutants for the Treatment of NSCLC. J Med Chem. 2025 Mar 13;68 (5) :5907-5925.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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