FGFR-IN-17
FGFR-IN-17 (Compound 12l) is an orally active irreversible inhibitor of FGFR, which has a strong inhibitory effect on FGFR and its mutants. FGFR-IN-17 can inhibit the proliferation and migration, and induce apoptosis of non-small cell lung cancer cells. FGFR-IN-17 has anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FGFR
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=CC(NC1=CC=C(NC2=NC(NC3=CC=C(N4C[C@@H](C)N[C@@H](C)C4)C(OC)=C3)=NC=C2Cl)C=C1Cl)=O
Molecular Formula
C26H29Cl2N7O2
Molecular Weight
542.46
References & Citations
[1]Zhang J, et al. Discovery of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent and Selective FGFR Inhibitors against Gatekeeper Mutants for the Treatment of NSCLC. J Med Chem. 2025 Mar 13;68 (5) :5907-5925.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV668136 1.0 µg DNA
IL10RB Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
Sign In for Pricing
View Details 
orb862443 2 mg
Customized Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic Antibody
Sign In for Pricing
View Details 