Tosposertib
Tosposertib is an ALK5/VEGFR2 dual inhibitor (IC50 = 1.2 nM/4.9 nM) . Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer[1].
Product Specifications
CAS Number
1418305-55-1
Product Name Alternative
TU2218 (free base)
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=CC(C(NC2=NCCN23)=C3C4=CN5N=CN=C5C=C4)=N1
Molecular Formula
C17H15N7
Molecular Weight
317.35
References & Citations
[1]Lee JY, et al., 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors. WO2013009140|[2]Kim NH, et al. ALK5/VEGFR2 dual inhibitor Tosposertib alone or in combination with immune checkpoint inhibitors enhances immune-mediated antitumor effects. Cancer Immunol Immunother. 2024 Aug 6;73 (10) :190.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Available Sizes
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