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PF-06842874

PF-06842874 is a CDK4/Cyclin D1 and CDK6/Cyclin D3 inhibitor (Ki values are 62 and 130 nM, respectively) . PF-06842874 can be used in the research of pulmonary arterial hypertension and cancer[1].

Product Specifications

CAS Number

2516247-98-4

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer; Cardiovascular Disease

Smiles

O=C1N(C2CCCC2)C3=CC(N[C@H]4[C@@H](COCC4)O)=NC=C3C(C)=C1C(C)=O

Molecular Formula

C21H27N3O4

Molecular Weight

385.46

References & Citations

[1]Samit Kumar BhattacharyaI, et al. Anti-proliferative agents for treating pah. WO2020212865A1. Pfizer Inc. 2020-04-15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK4; CDK6

Frequently Asked Questions

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