INCB-056868

INCB-056868 is the metabolite M11 of Epacadostat (HY-15689) . INCB-056868 can also serve as a substrate for BCRP. INCB-056868 is promising for research of metabolic diseases[1].

Product Specifications

CAS Number

[2252320-89-9]

UNSPSC

12352211

Target

BCRP; Drug Metabolite

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=S(N)(NCCNC1=NON=C1C(NC2=CC=C(C(Br)=C2)F)=N)=O

Molecular Formula

C11H13BrFN7O3S

Molecular Weight

422.23

References & Citations

[1]Zhang Q, et al. In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions. Drug Metab Dispos. 2017 Jun;45 (6) :612-623.