S-15176

S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP) . S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 value of 45.7 μM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD (P) H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury[1][2].

Product Specifications

CAS Number

[148089-70-7]

UNSPSC

12352005

Target

Mitochondrial Metabolism

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

OC1=C(C(C)(C)C)C=C(SCCCN2CCN(CC2)CC3=CC=C(C(OC)=C3OC)OC)C=C1C(C)(C)C

Molecular Formula

C31H48N2O4S

Molecular Weight

544.79

References & Citations

[1]Albengres E, et al. S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes. Fundam Clin Pharmacol. 2001 Feb;15 (1) :41-6.|[2]Elimadi A, et al. S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties. Eur J Pharmacol. 2003 May 9;468 (2) :93-101.