P2Y14R antagonist 3
P2Y14R antagonist 3 (Compound A) is a potent and orally active P2Y14R antagonist with an IC50 value of 23.60 nM and a Kd value of 7.26 μM. P2Y14R antagonist 3 can reduce the degree of lung injury in the Lipopolysaccharides (LPS) -induced acute lung injury mice. P2Y14R antagonist 3 can be used for inflammatory diseases[1].
Product Specifications
UNSPSC
12352005
Target
P2Y Receptor
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CNC(C1CN(CC12CCN(CC2)C(C3=NOC4=CC=CC=C43)=O)C(C5=C6C=CC=CC6=NO5)=O)=O
Molecular Formula
C26H25N5O5
Molecular Weight
487.51
References & Citations
[1]Wei Z, et al. Discovery of a potent and in vivo anti-inflammatory Efficacious, P2Y14R antagonist with a novel benzisoxazoles scaffold by DNA-encoded chemical library technology. Eur J Med Chem. 2025 Feb 27;289:117451.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y14 Receptor
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