[Ru (phen) 2 (HMPIP) ] (PF6) 2
[Ru (phen) 2 (HMPIP) ] (PF6) 2 (Compound 6A) is an anti-tumor agent. [Ru (phen) 2 (HMPIP) ] (PF6) 2 can inhibit the proliferation and migration of HepG2 liver cancer cells, and induce apoptosis, autophagy, cell cycle arrest and ferroptosis of HepG2 liver cancer cells. [Ru (phen) 2 (HMPIP) ] (PF6) 2 exerts its anti-tumor activity by stimulating immune response to increase CD8+ T cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; Ferroptosis
Related Pathways
Apoptosis; Autophagy
Field of Research
Cancer
Smiles
OC1=C(C)C=CC=C1C(N2)=NC3=C2C4=C([N]5=CC=C4)C6=[N]([Ru+2]785([N]9=CC=CC%10=C9C%11=[N]8C=CC=C%11C=C%10)[N]%12=C%13C(C=CC%14=C%13[N]7=CC=C%14)=CC=C%12)C=CC=C63.[F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Molecular Formula
C44H30F12N8OP2Ru
Molecular Weight
1077.76
References & Citations
[1]Tian S, et al. Ruthenium (II) polypyridyl complexes inhibit tumor growth through stimulating immune system to increase CD8+ T cell. Eur J Med Chem. 2025 Feb 28;289:117470.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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