PARP1/CDK12-IN-1
PARP1/CDK12-IN-1 (107) is a dual inhibitor of CDK12 and PARP1, with IC50 values of 285 nM and 34 nM for CDK12 and PARP1, respectively[1].
Product Specifications
UNSPSC
12352005
Target
CDK; PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
NC(C1=CC=CC2=C1N=C(NC(C3=CC=CC(C(N4CCC(NC5=NC=C(N=C5)I)CC4)=O)=C3)=O)N2)=O
Molecular Formula
C25H23IN8O3
Molecular Weight
610.41
References & Citations
[1]Qi Hao, et al. Combination therapy and dual-target inhibitors based on cyclin-dependent kinases (CDKs) : Emerging strategies for cancer therapy. Eur J Med Chem. 2025 May 5:289:117465.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; PARP1
Curated Selection
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