SOS1-IN-18
SOS1-IN-18 (Compound 8) is the inhibitor for Son of Sevenless 1 protein (SOS1) with a KD of 2.6 nM, and inhibits SOS1-KRAS G12C interaction with an IC50 of 3.4 nM. SOS1-IN-18 inhibits the phosphorylation of ERK in H358 with an IC50 of 31 nM, inhibits the proliferation of H358 with an IC50 of 5 nM[1].
Product Specifications
UNSPSC
12352005
Target
ERK; Ras; SOS1
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C=C2C(C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3C)C)=NC4=C2CNCC4)=CN1C5CCOCC5
Molecular Formula
C26H29F3N4O2
Molecular Weight
486.53
References & Citations
[1]Leffler A E, et al. Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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