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Lenalidomide-hex-5-ynoic acid

Lenalidomide-hex-5-ynoic acid is a conjugate of E3 ligase ligand and linker, and can be used to synthesize PROTACs, such as PROTAC cGAS degrader-1.

Product Specifications

CAS Number

2379870-47-8

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Others

Smiles

O=C(C(CC1)N(C2=O)CC(C2=CC=C3)=C3C#CCCCC(O)=O)NC1=O

Molecular Formula

C19H18N2O5

Molecular Weight

354.36

References & Citations

[1]He P, et al. Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis. J Med Chem. 2025 Mar 13;68 (5) :5551-5572.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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