Lenalidomide-hex-5-ynoic acid
Lenalidomide-hex-5-ynoic acid is a conjugate of E3 ligase ligand and linker, and can be used to synthesize PROTACs, such as PROTAC cGAS degrader-1.
Product Specifications
CAS Number
2379870-47-8
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Others
Smiles
O=C(C(CC1)N(C2=O)CC(C2=CC=C3)=C3C#CCCCC(O)=O)NC1=O
Molecular Formula
C19H18N2O5
Molecular Weight
354.36
References & Citations
[1]He P, et al. Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis. J Med Chem. 2025 Mar 13;68 (5) :5551-5572.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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