(3S,6R) -NML

(3S,6R) -NML is a NMDA receptor antagonist, with pIC50s of 4.8 (GluN1-GluN2A), 4.6 (GluN1-GluN2B), 5.0 (GluN1-GluN2C), 5.0 (GluN1-GluN2D) respectively. (3S,6R) -NML can be used for depression research[1].

Product Specifications

CAS Number

[1585965-04-3]

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC[C@H](O)C(C1=CC=CC=C1)(C2=CC=CC=C2)C[C@H](NC)C

Molecular Formula

C20H27NO

Molecular Weight

297.43

References & Citations

[1]Banzato M, et al. New Synthesis and Pharmacological Evaluation of Enantiomerically Pure (R) - and (S) -Methadone Metabolites as N-Methyl-d-aspartate Receptor Antagonists. J Med Chem. 2025 Feb 25.