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DDO-8958

DDO-8958 is an orally active and selective BET BD1 inhibitor with a KD of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity[1].

Product Specifications

CAS Number

3017180-18-3

UNSPSC

12352005

Target

Apoptosis; Epigenetic Reader Domain

Related Pathways

Apoptosis; Epigenetics

Field of Research

Cancer

Smiles

FC1=C(C=C(C=C1C2=C3NC=NC3=NC=C2)OCC4COC4)C5=C(N(N=C5C)C)C

Molecular Formula

C22H22FN5O2

Molecular Weight

407.44

References & Citations

[1]Chen X, et al. Multi-Water Bridges Enable Design of BET BD1-Selective Inhibitors for Pancreatic Cancer Therapy. J Med Chem. 2025 Mar 13;68 (5) :5719-5735.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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