DDO-8958
DDO-8958 is an orally active and selective BET BD1 inhibitor with a KD of 5.6 nM for BRD4 BD1. DDO-8958 exhibits low nanomolar inhibitory activity against all BET BD1 bromodomains except for BRDT BD1. DDO-8958 can inhibit the proliferation and migration, induce apoptosis and cell cycle arrest of tumor cells. DDO-8958 has anti-tumor activity[1].
Product Specifications
CAS Number
[3017180-18-3]
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
FC1=C(C=C(C=C1C2=C3NC=NC3=NC=C2)OCC4COC4)C5=C(N(N=C5C)C)C
Molecular Formula
C22H22FN5O2
Molecular Weight
407.44
References & Citations
[1]Chen X, et al. Multi-Water Bridges Enable Design of BET BD1-Selective Inhibitors for Pancreatic Cancer Therapy. J Med Chem. 2025 Mar 13;68 (5) :5719-5735.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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