SIRT-IN-7
SIRT-IN-7 (Compound 7ba) is a SIRT inhibitor. SIRT-IN-7 can inhibit the expression of SIRT1, SIRT2, and SIRT3, and increase the acetylation and activation of p53. SIRT-IN-7 can inhibit the proliferation, and induce apoptosis and autophagy of breast cancer cells. SIRT-IN-7 has anti-tumor activity[1].
Product Specifications
CAS Number
[1620634-65-2]
UNSPSC
12352005
Target
Apoptosis; Autophagy; MDM-2/p53; Sirtuin
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
ClC1=CC2=C(N=C(NC(C3=C(C=CC4=C3C=CC=C4)O)C5=CC=C(C=C5)Br)S2)C=C1
Molecular Formula
C24H16BrClN2OS
Molecular Weight
495.82
References & Citations
[1]Kojja V, et al. 2- (Diarylalkyl) aminobenzothiazole derivatives induce autophagy and apoptotic death through SIRT inhibition and P53 activation In MCF7 breast cancer cells. Comput Biol Chem. 2025 Jun;116:108395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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