PD-L1/HDAC6-IN-1
PD-L1/HDAC6-IN-1 (Compound HP29) is the inhibitor for PD-L1 and HDAC6 that inhibits the PD-L1/PD-1 interaction and HDAC6 with an IC50 of 26.8 nM and 69 nM. PD-L1/HDAC6-IN-1 enhances the killing ability of Jurkat T cells against HepG2 cells with an IC50 of 3.4 μM. PD-L1/HDAC6-IN-1 exhibits good pharmacokinetics characteristics in rats with a drug exposure of 871.62 ng·h/mL, and exhibits antitumor activity in mouse B16-F10 xenograft models[1].
Product Specifications
CAS Number
2834094-36-7
UNSPSC
12352005
Target
HDAC; PD-1/PD-L1
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Field of Research
Cancer
Smiles
CC1=C(C=CC=C1C2=CC=CC=C2)C3=NC(OC)=C(C=C3)CNCCCCCCC(NO)=O
Molecular Formula
C27H33N3O3
Molecular Weight
447.57
References & Citations
[1]Hu Z, et al., Discovery of Novel and Highly Potent Dual PD-L1/Histone Deacetylase 6 Inhibitors with Favorable Pharmacokinetics for Cancer Immunotherapy. J Med Chem. 2025 Mar 13;68 (5) :5426-5454.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6
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