GSK3-IN-10
GSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress[1].
Product Specifications
CAS Number
[844441-56-1]
UNSPSC
12352005
Target
CDK; CDKL; DYRK; GSK-3; JNK; β-catenin
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C(C1=NNC=C1NC(C2=C(F)C=CC=C2F)=O)NCC3CCOCC3
Molecular Formula
C17H18F2N4O3
Molecular Weight
364.35
References & Citations
[1]Ong HW, et al., Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chem Neurosci. 2023 May 3;14 (9) :1672-1685.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDKL5; CLK; DYRK1; DYRK2; GSK-3α; GSK-3β; JNK3
Curated Selection
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