GSK3-IN-10

GSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress[1].

Product Specifications

CAS Number

[844441-56-1]

UNSPSC

12352005

Target

CDK; CDKL; DYRK; GSK-3; JNK; β-catenin

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

O=C(C1=NNC=C1NC(C2=C(F)C=CC=C2F)=O)NCC3CCOCC3

Molecular Formula

C17H18F2N4O3

Molecular Weight

364.35

References & Citations

[1]Ong HW, et al., Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chem Neurosci. 2023 May 3;14 (9) :1672-1685.