JNJ-3738
JNJ-3738 (Compound 148) is the inhibitor for CDK7 with a Ki of 21.75 nM. JNJ-3738 inhibits the proliferation of CDK7 WT expressing A549 with pIC50 of 7.37[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C[C@@H]1C2=C(N3CCS(=O)(CC3)=O)N=CN=C2NC4=CC(C5CCN(C6CN(C6)C(C#CC)=O)CC5)=CC(C)=C4O1
Molecular Formula
C29H36N6O4S
Molecular Weight
564.70
References & Citations
[1]Stansfield I, et al., Tricyclic pyrimidines as cyclin-dependent kinase 7 (cdk7) inhibitors. WO2022136174
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172194/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[2796279-20-2]
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