JNJ-3738

JNJ-3738 (Compound 148) is the inhibitor for CDK7 with a Ki of 21.75 nM. JNJ-3738 inhibits the proliferation of CDK7 WT expressing A549 with pIC50 of 7.37[1].

Product Specifications

CAS Number

[2796279-20-2]

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

C[C@@H]1C2=C(N3CCS(=O)(CC3)=O)N=CN=C2NC4=CC(C5CCN(C6CN(C6)C(C#CC)=O)CC5)=CC(C)=C4O1

Molecular Formula

C29H36N6O4S

Molecular Weight

564.70

References & Citations

[1]Stansfield I, et al., Tricyclic pyrimidines as cyclin-dependent kinase 7 (cdk7) inhibitors. WO2022136174

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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