UBD1031
UBD1031 (SGC-UBD1031) is a potent USP16-UBD and HDAC6-UBD antagonist, with Kd values of 48 and 16 nM, respectively. UBD1031 inhibits the interaction between USP16 and ISG15 with an EC50 of 1.7 nM. UBD1031 can be used a chemical probe for USP16 UBD[1][2].
Product Specifications
Product Name Alternative
SGC-UBD1031
UNSPSC
12352005
Target
Deubiquitinase; HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
OC(CCC1=NC2=C(C(N1CC(N[C@@H](C)C3=C(C=CC=C3F)F)=O)=O)C=CC=C2Cl)=O
Molecular Formula
C21H18ClF2N3O4
Molecular Weight
449.84
References & Citations
[1]SGC-UBD1031 A probe with dual USP16-HDAC6 activity.|[2]Silva M, et al. Development of a dual chemical probe for the USP16 and HDAC6 zinc-finger ubiquitin-binding domain. bioRxiv, 2025: 2025.10. 23.684218.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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