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ONO-2920632

ONO-2920632 is an orally active and central nervous system (CNS) -penetrant TREK activator, with EC50 values of 0.3 µM and 2.8 μM for TREK-1 and TREK-2, respectively. ONO-2920632 exhibits selectivity for other K2P channels (>91-fold selective versus TASK1, TASK2, TASK3, TRAAK, and TWIK2; 31-fold selective versus TRESK) . ONO-2920632 possesses analgesic effects and can be used in research on pain, migraine, and neurological disorders.

Product Specifications

CAS Number

[2230296-66-7]

Product Name Alternative

VU6011887

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CN2C(C=C1)=NC=N2)NCC3=CC=C(OC(F)(F)F)C=C3F

Molecular Formula

C15H10F4N4O2

Molecular Weight

354.26

References & Citations

[1]Yashiro K, et al. Discovery of ONO-2920632 (VU6011887) : A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound. ACS Chem Neurosci. 2025 Mar 5;16 (5) :960-967.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-172182/ONO-2920632-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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