EGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2 with an IC50 value of 1.15 µM for VEGFR2 and an IC50 value of 0.28 μM for EGFRT790M. EGFR/VEGFR2-IN-5 has significant anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
EGFR; VEGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(O)C1=CC=CC=C1/N=N/C2C(NC(NS(=O)(C3=CC=C(N)C=C3)=O)=NC2=N)=O
Molecular Formula
C17H15N7O5S
Molecular Weight
429.41
References & Citations
[1]Alsulaimany M, et al. Dual VEGFR-2 and EGFRT790M inhibitors of phenyldiazenes: anticancer evaluations, ADMET, docking, design and synthesis. Future Med Chem. 2025 Feb;17 (3) :287-300. doi: 10.1080/17568919.2025.2453409. Epub 2025 Jan 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; VEGFR2/KDR/Flk-1
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