HYS-072
HYS-072 is an orally active derivative of chrysin (HY-14589) with antitumor activity. HYS-072 induces apoptosis and autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway and suppresses tumor growth in vivo in xenograft models by modulating autophagy-related pathways. HYS-072 can be used in the research of triple-negative breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Autophagy; mTOR; PI3K
Related Pathways
Apoptosis; Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC1=CC=C(NC(NCCCCOC2=CC(O)=C3C(OC(C4=CC=CC=C4)=CC3=O)=C2)=O)C=C1
Molecular Formula
C27H26N2O5
Molecular Weight
458.51
References & Citations
[1]Hou Y, et al. A novel chrysin derivative HYS-072 induces apoptosis and autophagy in Triple-negative breast cancer cells. Nat Prod Res. 2025 Feb 11:1-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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